First off, I started on the TLT Speed, and I love those bindings. Light, easy to use after you learn them, and enough performance for me to take on any terrain. After moving those to a new set of skis, I got the Verticals and put them on the old skis. Primary reason was that I wanted ski brakes for area use.
Well, the ski brakes work. The setup is noticeably heavier. Other benefits vs. the Speed: the toe tensioner is a lot easier to activate, they are even easier to get into (the toe prongs start closer to the boot), and the heel lifter is more user-friendly (you get more than one position to insert your pole).
All in all, I would recommend the Speed over the Vertical unless one of these conditions apply to you: 1. you need ski brakes / hate leashes, 2. you need more than +/- .5 mondo adjustment range. Otherwise, I don't think the benefits are worth the increase in weight.