I am obsessed with running and own all 10 socks from runnersworld.com's review of the top 10 socks of 08' and Injinji (which was in there) is the best sock to wear to prevent blisters. It is comfortable, breathable and is a nice sock to wear around the house or during a marathon. I run 5 miles+ a day and should know that these socks work. Now its obvious that the socks won't last as long as normal socks because of the toes, they wear faster yes but unless you're running more than 50 miles a week, they will last you a good while. I've had mine a month and they work as good as the first run. Don't worry about getting used to the toes. Men, dont be ashamed to wear these socks, they work. Now they are a little tough to get on at first but it gets easier. I would advise to getting Pearl Izumi socks as well, they are just as amazing.